About the Lab
The Yassine lab specializes in how changes in lipid metabolism and nutrition affect the brain and risk of developing Alzheimer’s disease (AD). The lab has a specific interest in studying how carrying the APOE4 allele, strongest genetic risk factors for developing AD, and diabetes affect brain lipid metabolism and the response to the diet. Our approach combines basic science, clinical trials and brain imaging studies.
Research News
Sex‐Related Differences in Cognitive Trajectories in Older Individuals With Type 2 Diabetes and Overweight or Obesity
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Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes
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Can we image brain lipid inflammation associated with APOE4 Alzheimer's? Collaboration with Kai Chen from the Department of Radiology, @KECKSchool_USC, 18-F AA synthesis and PET imaging led by Juno Van Valkenburgh and Marlon Duro, now published in PLEFA: https://www.sciencedirect.com/science/article/pii/S0952327822001223?dgcid=author
In this work led by Alireza Nazarian, the APOE4 locus was associated with lipids (PUFAs) and whereas APOE2 with polar metabolites (glutamine), raising the possibility that a different preference for mitochondrial fuel confers susceptibility to AD risk: https://www.frontiersin.org/articles/10.3389/fnagi.2022.1023493/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Aging_Neuroscience&id=1023493
Leclerc et al. report that cerebral insulin receptors localized at the blood-brain barrier are defective in Alzheimer’s disease, contributing to brain insulin resistance. https://bit.ly/3f9LJBv
Join The Yassine Lab
We are seeking for postdoctoral researchers to join our lab. Contact our team below for more information.