About the Lab
The Yassine lab specializes in how changes in lipid metabolism and nutrition affect the brain and risk of developing Alzheimer’s disease (AD). The lab has a specific interest in studying how carrying the APOE4 allele, strongest genetic risk factors for developing AD, and diabetes affect brain lipid metabolism and the response to the diet. Our approach combines basic science, clinical trials and brain imaging studies.
Research News
Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?
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For the first time, we measure HDL particles in cerebrospinal fluid and discover that greater levels of small HDL correlate with better cognitive performance and less accumulation of brain amyloid. What promotes small HDL formation in the brain? https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12649
Due to an irregularity in one of the figures, we decided to retract our paper and resubmit it with new experiments. We are committed to principles of scientific rigor. https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-022-00519-x
Thanks @ISTAART & #ClinicalTrialsPIA our articles examining the mismatch between the observational and clinical trial evidence for dementia risk reduction now out - suggestions incl for possible ways forward @ErinAbnerPhD https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12393
Join The Yassine Lab
We are seeking for postdoctoral researchers to join our lab. Contact our team below for more information.