APOE, the Diet and Alzheimer’s disease

How does the diet interact with APOE Alleles to increase the risk of Alzheimer’s disease?

The APOE gene alleles modify human aging and the response to the diet at many levels with diverse pleiotropic effects from gut to brain. To understand the interactions of APOE isoforms and diet on the brain, check this recent article authored by Drs. Hussein Yassine and Caleb E. Finch. The review provides deep insights from basic science to clinical trials into how the ancestral APOE Allele, APOE4, interacts with modern-day diets affecting brain aging and Alzheimer’s disease risk.

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