Proceedings of the Nutrition for Dementia Prevention Working Group Symposium

The Nutrition for Dementia Prevention working group was formed in 2020 by an international group of experts to address the following paradox: observational studies reveal an association between a healthy diet or dietary components and better brain health, but clinical trials investigating healthy diets or supplements have not shown convincing clinical benefit. Over the past two years, the working group examined the limitations of existing trials and provided a roadmap for designing newer studies and trials that can address past limitations and move the field forward. We thank the National Institute on Aging at NIH and the Alzheimer Association for supporting this work. A symposium was held in July of 2021 to debate these findings. The proceedings of this symposium are now published in Lancet Healthy Longevity

Figure 2: Two contrasting study designs for nutrition-based interventions for dementia prevention
Two contrasting approaches to nutrition-based clinical trials are shown. The first column shows intensive and personalized interventions guided by biomarkers that capture brain functions. In the second column, interventions are tailored to a population level in groups at risk of dementia and uses pragmatic outcomes. Although certain trials will have to share elements from both approaches, clear study designs that match the intensity of the intervention with the outcome proposed promise to maximise the chances of finding effective therapies

Leave a Comment

Your email address will not be published.