Why would APOE4 carriers with dementia not benefit from omega-3 supplementation? In this work, Brandon Ebright led our team in collaboration with RUSH Medical Center in analyzing brain autopsy tissues of the Religious Order Study and found a striking pattern of omega-3 and omega-6 breakdown lipid products in APOE4 with dementia but not in APOE4 without dementia. Chronic activation of inflammatory pathways may offset any benefit of omega-3 supplementation in this case. We then identified those pathways. Can lowering brain inflammation reverse the progression of APOE4 dementia?