Happy to announce that our next project just received NIH funding! This is a collaborative teamwork among my lab and the labs of Meredith Braskie and Matt Borzage to understand how diabetes affects brain vascular function. We use state-of-the-art 7T brain MRIs, examining cerebrovascular reactivity, brain connectivity, and blood-brain barrier integrity in an underserved population …
Why would APOE4 carriers with dementia not benefit from omega-3 supplementation? In this work, Brandon Ebright led our team in collaboration with RUSH Medical Center in analyzing brain autopsy tissues of the Religious Order Study and found a striking pattern of omega-3 and omega-6 breakdown lipid products in APOE4 with dementia but not in APOE4 …
APOE4 and brain inflammation in the Religious Order Study Read More »
Over the past 4 years, Juno Van Valkenburg and Marlon Duro synthesized 18-F Arachidonic Acid (AA) to image brain lipid inflammation in mice models of APOE4. This is a collaboration between my Lab and that of Kai Chen from the Department of Radiology, at Keck School of Medicine. The advantage of 18-F AA is its …
The Nutrition for Dementia Prevention working group was formed in 2020 by an international group of experts to address the following paradox: observational studies reveal an association between a healthy diet or dietary components and better brain health, but clinical trials investigating healthy diets or supplements have not shown convincing clinical benefit. Over the past …
Proceedings of the Nutrition for Dementia Prevention working group Symposium Read More »
In this collaboration with Artery Therapeutics, Sasan Noveir, Bilal Kerman and the team show that a peptide that makes HDL promotes the clearance of amyloid from the brain in cynomolgus monkeys. The study looked at the effects of a synthetic peptide (CS-6253) on biomarkers relevant to Alzheimer’s Disease in cynomolgus monkeys, a species that shares …
Does making new HDL particles affect Alzheimer’s disease? Read More »
‘Good’ cholesterol may decrease your risk of Alzheimer’s disease
Over the past 7 years, our team succeeded in developing an assay to measure brain HDL using the Ion Mobility Technique. This method was originally developed for blood lipoproteins by our long-term collaborator Ronald Krauss at UCSF. Congratulations to Ashley Martinez (who led the biochemistry studies to isolate HDL from cerebrospinal fluid), Gali Weissberger (who …
Discovery of small HDL in CSF as an Alzheimer’s biomarker Read More »
We are seeking an enthusiastic, detail-oriented applicant for the position of Postdoctoral Fellow to join a multi-disciplinary NIH-funded team led by Dr. Hussein Yassine in close collaboration with several basic sciences, imaging, and clinical research programs at USC. The Keck School of Medicine is one of the nation’s leading medical schools, ranked in the top …
PET image of the brain of an APOE4 mouse model injected with a radioactive arachidonic acid tracer. Red areas show arachidonic acid, a type of fatty acid. The Yassine Lab uses this technology to study how APOE4 affects brain lipids and inflammation.
