Brain Omega-3 Program
- In this program, we study mechanisms of how to prevent APOE4 genotype from increasing the risk of Alzheimer’s disease or vascular dementia using animal studies, brain imaging and clinical trials by focusing on fatty acid brain metabolism and neuroinflammation.
- These are the fundamental questions our lab is trying to answer:
- Can high dose omega-3 slow down cognitive decline in younger cognitively healthy APOE4 carriers before the onset of dementia?Can inhibition of cPLA2 offset neuroinflammation in APOE4 carriers with prodromal Alzheimer’s disease?
- Can we develop imaging biomarkers of omega-3 and omega-6 fatty acid uptake to guide the response of the diet and cPLA2 inhibition?