Brain Omega-3 Program
- In this program, we study mechanisms of how to prevent APOE4 genotype from increasing the risk of Alzheimer’s disease or vascular dementia using animal studies, brain imaging and clinical trials by focusing on fatty acid brain metabolism and neuroinflammation.
- These are the fundamental questions our lab is trying to answer:
- Can high dose omega-3 slow down cognitive decline in younger cognitively healthy APOE4 carriers before the onset of dementia?
- Can inhibition of cPLA2 offset neuroinflammation in APOE4 carriers with prodromal Alzheimer’s disease?
- Can we develop imaging biomarkers of omega-3 and omega-6 fatty acid uptake to guide the response of the diet and cPLA2 inhibition?
Funding
Brain Omega-3 Program
Brain HDL program
Association Between Saturated Fatty Acid-Containing Phosphatidylcholine in CSF with Tau Phosphorylation
Previous studies in animal models have indicated that saturated fatty acids play a role in neurodegeneration. Yet in humans, more research is needed in order
May 30, 2022
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Brain Omega3 Program
How does APOE4 increase the risk of Alzheimer’s disease dementia?
An interview with Julie Gregory from the APOE4 Info forum, on how APOE4 increases the risk of dementia, and what we can do about it
October 29, 2021
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