Publications Yassine HNSex specific associations of sex hormones with brain volumes and cerebral blood flow: A cross sectional observational study within the look AHEAD type 2 diabetes cohort August 31, 2025CONCLUSIONS: In postmenopausal females with Type 2 Diabetes with overweight and obesity, detectable levels of total testosterone were associated greater brain volume relative to intracranial volume, suggesting a protective role for testosterone in female brain health. Our findings are limited by a small sample size and low sensitivity of hormone assays. Our suggestive findings can […] Dhananjay VaidyaAutomatic detection of arterial input function for brain DCE-MRI in multi-site cohorts August 14, 2025CONCLUSION: Findings suggest a 3D UNet model with additional convolutional neural network kernels and a modified Huber loss function achieves superior performance for identifying AIF curves from DCE-MRI in a diverse multi-center cohort. AIFitness scores and DCE-MRI-derived metrics, such as K^(trans) maps, showed no significant differences in gray and white matter between manually drawn and […] Lucas SacaIncreased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers July 9, 2025The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites; however, the impact and function of this glycosylation on AD biomarkers remain unclear. We examined apoE glycosylation (total and secondary) in a cohort of cerebrospinal fluid […] Dobrin NedelkovHigh precision and cost-effective multiplex quantification of amyloid-β40, amyloid-β42, p181Tau, p217Tau, neurofilament light chain, and glial fibrillary acidic protein from plasma and serum May 13, 2025BackgroundCurrent methods to quantify blood biomarkers for Alzheimer's disease (AD) are expensive and are not widely available.ObjectiveTo develop a low-cost, sensitive, and accurate multiplex assay to quantify Aβ(40), Aβ(42), p181Tau, p217Tau, NfL, and GFAP biomarkers in plasma and serum based on a widely available technology.MethodsWe used commercial antibodies to Aβ(40), Aβ(42), p181Tau, p217Tau, NfL, and […] Farshad AlishahiEvidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology April 16, 2025CONCLUSIONS: cPLA2 overactivation at synapses, dendrites, and excitatory neuronal somas is associated with synaptic loss, neuritic plaques and neurodegeneration, potentially contributing to cognitive decline in AD. Future research needs to explore the role of cPLA2 as a disease-modifying target for AD. Qiu-Lan MaCerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers April 12, 2025Cerebral blood flow (CBF) deficits, cognitive decline, and brain structural changes have been reported in older adults with and without apolipoprotein E-e4 (APOE4)-related risk for dementia. However, it remains unclear whether brain structural changes mediate the effects of hypoperfusion on cognitive impairment in APOE4 carriers and non-carriers. We studied 166 (60-89 years) APOE4 carriers (ε3/ε4 […] Ioannis PappasCellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD February 3, 2025CONCLUSIONS: Oxysterol accumulation in APOE4 and AD induced ABCA1 and caveolin-1 expression, contributing to lysosomal dysfunction and increased cellular senescence markers. This study provides novel insights into how cholesterol metabolism accelerates features of brain cellular senescence pathway and identifies therapeutic targets to mitigate these processes. Shaowei WangIncreased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers January 7, 2025The apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for Alzheimer's disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites, yet the impact and function of this glycosylation on AD biomarkers remains unclear. We examined apoE glycosylation in a cohort of cerebrospinal fluid (CSF, n=181) […] Dobrin NedelkovDevelopment of Calcium-Dependent Phospholipase A2 Inhibitors to Target Cellular Senescence and Oxidative Stress in Neurodegenerative Diseases November 22, 2024Significance: Cellular senescence is a critical process underlying aging and is associated with age-related diseases such as Alzheimer's disease. Lipids are implicated in cellular senescence. Fatty acids, particularly eicosanoids, have been associated with various forms of senescence and inflammation, and the associated reactive oxygen species production has been proposed as a therapeutic target for mitigating […] Cristelle HugoAPOE ε4 and Dietary Patterns in Relation to Cognitive Function: An Umbrella Review of Systematic Reviews November 5, 2024CONCLUSION: This review identifies notable gaps in the literature, such as a shortage of studies conducted in middle-aged and cognitively healthy APOE ε4 carriers assessing the impact of dietary interventions and provides suggestions for novel trial designs. Thomas J UrichDesigning Newer Omega-3 Supplementation Trials for Cognitive Outcomes: A Systematic Review Guided Analysis October 18, 2024CONCLUSIONS: We recommend that newer n-3 PUFA supplement trials targeting AD prevention be personalized. For the general population, the null hypothesis appears to be correct, and future interventions are needed to identify and test dietary patterns that include PUFA-rich food rather than supplements. Hussein N YassineAdvancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference July 20, 2024INTRODUCTION: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link […] Courtney M KloskeSex Specific Associations of Sex hormone With Brain Volumes and Cerebral Blood Flow: A Cross Sectional Observational Study Within the Look AHEAD Type 2 Diabetes Cohort May 15, 2024CONCLUSIONS: In postmenopausal females with Type 2 Diabetes with overweight and obesity, detectable levels of total testosterone were associated greater brain volume relative to intracranial volume, suggesting a protective role for testosterone in female brain health. Our findings are limited by a small sample size and low sensitivity of hormone assays. Our suggestive findings can […] Dhananjay VaidyaEffects of APOE4 on omega-3 brain metabolism across the lifespan April 12, 2024Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural integrity. As Alzheimer's disease (AD) pathology progresses, DHA metabolism in the brain becomes dysregulated, the timing and extent of which may be influenced by the […] Brandon EbrightCan the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition? January 3, 2024PURPOSE OF REVIEW: Most omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation clinical trials report inconsistent or null findings on measures of cognition or Alzheimer's disease (AD) with a relatively large variability in the response to n-3 PUFA supplementation. The purpose of this review is to identify whether the gut microbiome together with the metabolome can […] Bilal E Kerman Publication information not available
